Principal Software Engineer (Genomics)

Company: Regeneron Pharmaceuticals, Inc.
Location: Tarrytown
Posted on: January 27, 2026

Job Description:

SUMMARY: We are seeking a Principal Software Engineer (Genomics), who can help develop and maintain computational software, tools, and applications to analyze and interpret millions of sequenced and deeply phenotyped human samples. To enable Regeneron to deliver better medicines to patients, we must empower our scientists to efficiently generate and interact with association analysis results from massive human genetics experiments. You will deliver high-quality, production-level, and flexible tools that help scientists perform large scale genomic analysis and explore and interpret their results. A proven track record of implementing software and pipelines in a cloud-based computing environment (such as Amazon Web Services or Google Cloud Platform) is essential for this role. As Principal Software Engineer (Genomics), a typical day may include: Design and implement software applications to fit users needs based on shifting state-of-the-art genetic analysis methods, opportunities and priorities. Modernize and optimize existing code bases to improve performance and create scalable, portable, unit tested code. Designing and maintaining robust, cloud-based genomic analysis platforms capable of processing petabytes of genomic data. Implementing comprehensive data management solutions that ensure FAIR data principles. Interact with other developers on the team and jointly develop code to address high-priority tasks. Provide user support by answering questions, understanding specific use cases, fixing bugs, and writing documentation. This role could be for you if you: Have a strong foundation in the current best practices of software engineering. Enjoy developing tools and solving challenging problems to aid scientists in performing creative analysis. Have a proven record of implementing scalable software tools, applications and workflows and in a cloud-based computing environment. Enjoy directly interacting with users to identify and develop solutions for their needs. Skilled in software development and is familiar or has a strong interest in human genetics or computational genomics. Can effectively communicate methods and present code to a variety of technical audiences. Enjoy working in a highly interactive environment with a diverse team of colleagues. To be considered for this role, you must have: At least a Masters degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field with at least 6 years of relevant experience in Computational Biology or a related field. A Doctoral degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field is also encouraged. Extensive experience with cloud computing platforms (AWS, GCP, or Azure) and containerization technologies. Strong background in developing and optimizing high-performance computing solutions for large-scale genomic data analysis. Proven experience with version control systems, CI/CD pipelines, and other modern software development practices. Deep expertise in multiple programming languages (e.g., Python, C++) and experience with genomic analysis tools. Experience building and maintaining databases and API layers is preferred. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regenerons roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regenerons on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $128,600.00 - $210,000.00

Keywords: Regeneron Pharmaceuticals, Inc., Parsippany-Troy Hills Township , Principal Software Engineer (Genomics), IT / Software / Systems , Tarrytown, New Jersey